Barrios Vicente, Puebla-Jiménez Lilian, del Carmen Boyano-Adánez María, Sanz Manuel, Soriano-Guillén Leandro, Arilla-Ferreiro Eduardo
Research Laboratory, Universidad Autónoma, Hospital Infantil Universitario Niño Jesús, Avda. Menéndez Pelayo, 65; 28009 Madrid, Spain.
Life Sci. 2005 Jul 22;77(10):1094-105. doi: 10.1016/j.lfs.2005.01.019.
Chronic ethanol ingestion decreases the number of somatostatin (SRIF) receptors in the rat frontoparietal cortex and female sex hormones modulate the effects of ethanol in the brain. Therefore, we investigated the differential effects of ethanol consumption on the SRIFergic system in the frontoparietal cortex of virgin and parturient rats given ethanol in their drinking water before and during gestation. In parturient rats, ethanol consumption decreased the density of SRIF receptors (25%, p<0.01 vs control parturient group) whereas the SRIF-like immunoreactivity (SRIF-LI) content was increased (140%, p<0.01). In virgin rats, ethanol ingestion decreased the density of SRIF receptors (42%, p<0.01) more than in alcoholic parturient rats. SRIF-LI levels were unaffected. The inhibitory effect of SRIF on basal and forskolin-stimulated adenylyl cyclase was significantly lower in alcoholic virgin rats as compared to alcoholic parturient rats. No differences in the levels of the G inhibitory (Gi) alpha1 and Gialpha2 proteins were observed among the experimental groups. These results suggest that gestation may confer partial resistance to the ethanol-induced effect on the SRIFergic system.
长期摄入乙醇会减少大鼠额顶叶皮质中生长抑素（SRIF）受体的数量，并且女性性激素会调节乙醇在大脑中的作用。因此，我们研究了在妊娠前和妊娠期间给处女鼠和分娩期大鼠饮用含乙醇的水，乙醇摄入对其额顶叶皮质中SRIF能系统的不同影响。在分娩期大鼠中，乙醇摄入降低了SRIF受体的密度（降低25%，与对照组分娩期大鼠相比，p<0.01），而生长抑素样免疫反应性（SRIF-LI）含量增加（增加140%，p<0.01）。在处女鼠中，乙醇摄入比酒精性分娩期大鼠更显著地降低了SRIF受体的密度（降低42%，p<0.01）。SRIF-LI水平未受影响。与酒精性分娩期大鼠相比，酒精性处女鼠中SRIF对基础和福斯可林刺激的腺苷酸环化酶的抑制作用显著降低。各实验组之间未观察到G抑制（Gi）α1和Giα2蛋白水平的差异。这些结果表明，妊娠可能使机体对乙醇诱导的SRIF能系统效应产生部分抗性。
