Department of Psychology & Neuroscience, University of North Carolina, Chapel Hill, NC, 27599, USA; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, 27599, USA.
Department of Psychology & Neuroscience, University of North Carolina, Chapel Hill, NC, 27599, USA; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, 27599, USA.
Neuropharmacology. 2020 May 1;167:107983. doi: 10.1016/j.neuropharm.2020.107983. Epub 2020 Feb 3.
In recent years, neuropeptides which display potent regulatory control of stress-related behaviors have been extensively demonstrated to play a critical role in regulating behaviors associated with substance abuse and affective disorders. Somatostatin (SST) is one neuropeptide known to significantly contribute to emotionality and stress behaviors. However, the role of SST in regulating behavior has received relatively little attention relative to other stress-involved peptides, such as neuropeptide Y or corticotrophin releasing factor. This review characterizes our current understanding of the role of SST and SST-expressing cells in general in modulating several behaviors intrinsically linked to substance abuse and affective disorders, specifically: anxiety and fear; stress and depression; feeding and drinking; and circadian rhythms. We further summarize evidence of a direct role for the SST system, and specifically somatostatin receptors 2 and 4, in substance abuse disorders. This article is part of the special issue on 'Neuropeptides'.
近年来，大量研究表明，具有强大应激相关行为调节作用的神经肽在调节与物质滥用和情感障碍相关的行为方面起着关键作用。生长抑素（SST）是一种已知的对情绪和应激行为有重要贡献的神经肽。然而，与其他涉及应激的肽，如神经肽 Y 或促肾上腺皮质素释放因子相比，SST 在调节行为方面的作用相对较少受到关注。本文综述了我们目前对 SST 及其表达细胞在调节几种与物质滥用和情感障碍内在相关的行为中的作用的理解，特别是：焦虑和恐惧；应激和抑郁；摄食和饮水；以及昼夜节律。我们进一步总结了 SST 系统，特别是生长抑素受体 2 和 4，在物质滥用障碍中的直接作用的证据。本文是“神经肽”特刊的一部分。
