Dandara Collet, Ballo Robea, Parker M Iqbal
MRC/UCT Oesophageal Cancer Research Group, Division of Medical Biochemistry, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa.
Cancer Lett. 2005 Jul 28;225(2):275-82. doi: 10.1016/j.canlet.2004.11.004. Epub 2004 Dec 25.
CYP3A5 is the major cytochrome P450 enzyme in the oesophagus and metabolises many potentially carcinogenic compounds. The frequencies of CYP3A5 allelic variants, CYP3A5*2, *3, *6 and 7 which code for enzymes with severely decreased activities were compared between 241 oesophageal cancer patients and 272 controls in Black and Mixed Ancestry South Africans. A significantly higher frequency of CYP3A53 was observed in the controls compared to patients amongst the Mixed Ancestry group (P=0.025). Individuals homozygous for defective CYP3A5 had reduced risk of developing oesophageal cancer (P=0.032).
CYP3A5是食管中主要的细胞色素P450酶，可代谢许多潜在的致癌化合物。在南非黑人和混合血统人群中，对241例食管癌患者和272例对照者的CYP3A5等位基因变体CYP3A5*2、3、6和7的频率进行了比较，这些变体编码的酶活性严重降低。在混合血统组中，与患者相比，对照组中CYP3A53的频率显著更高（P=0.025）。CYP3A5缺陷纯合子个体患食管癌的风险降低（P=0.032）。
