Kyzas Panayiotis A, Stefanou Dimitrios, Batistatou Anna, Agnantis Niki J
Department of Pathology, University of Ioannina, Medical School, Ioannina, Greece.
Cancer Lett. 2005 Jul 28;225(2):297-304. doi: 10.1016/j.canlet.2004.11.060. Epub 2005 Jan 18.
Numerous studies indicate the importance of hypoxia-induced pathway in tumor angiogenesis, but in vivo studies examining the importance of this mechanism in prognosis of patients with head and neck squamous cell carcinoma present conflicting results. We performed a retrospective analysis of 81 patients with head and neck squamous cell carcinoma in order to investigate whether hypoxia-inducible factor 1a (HIF-1a) immunohistochemical expression correlates with vascular endothelial growth factor (VEGF) expression and clinicopathologic parameters or prognosis. Our results showed a statistically significant association between HIF-1a and VEGF expression in tumors located in the lower lip and in larynx, but not in those located in the oral cavity. HIF-1a expression had no impact on prognosis, while VEGF expression correlated significantly with adverse prognosis. These findings support the hypothesis that tumor angiogenesis is close related, but not strictly dependent, on the hypoxic conditions of tumor's microenvironment.
大量研究表明缺氧诱导途径在肿瘤血管生成中具有重要性，但关于该机制在头颈部鳞状细胞癌患者预后中的重要性的体内研究结果相互矛盾。我们对81名头颈部鳞状细胞癌患者进行了回顾性分析，以研究缺氧诱导因子1α（HIF-1α）免疫组化表达是否与血管内皮生长因子（VEGF）表达、临床病理参数或预后相关。我们的结果显示，在下唇和喉部肿瘤中，HIF-1α与VEGF表达之间存在统计学上的显著关联，但在口腔肿瘤中则不存在。HIF-1α表达对预后没有影响，而VEGF表达与不良预后显著相关。这些发现支持了肿瘤血管生成与肿瘤微环境的缺氧状态密切相关但并非严格依赖的假说。
