Maderna Paola, Godson Catherine
Department of Medicine and Therapeutics, The Conway Institute of Biomolecular and Biomedical Research and The Dublin Molecular Medicine Centre, University College Dublin, Belfield, Dublin 4, Ireland.
Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct;73(3-4):179-87. doi: 10.1016/j.plefa.2005.05.004.
Phagocytic clearance of apoptotic cells plays a pivotal role in the resolution of inflammation. Recent evidence has shown that such processes can be regulated by endogenous mediators, suggesting that specific mimetics may have therapeutic potential in chronic inflammation and autoimmune disorders. Here we review the mechanisms underlying recognition and engulfment of apoptotic cells and regulation of these processes by lipoxins and lipoxin receptor agonists.
凋亡细胞的吞噬清除在炎症消退中起关键作用。最近的证据表明，此类过程可受内源性介质调节，这表明特定的模拟物在慢性炎症和自身免疫性疾病中可能具有治疗潜力。在此，我们综述凋亡细胞识别与吞噬的潜在机制以及脂氧素和脂氧素受体激动剂对这些过程的调节作用。
