Stickgold Robert, Walker Matthew P
Center for Sleep and Cognition, Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center E/FD 861, 330 Brookline Avenue, Boston MA 02215, USA.
Trends Neurosci. 2005 Aug;28(8):408-15. doi: 10.1016/j.tins.2005.06.004.
Memory consolidation and reconsolidation reflect molecular, cellular and systems-level processes that convert labile memory representations into more permanent ones, available for continued reactivation and recall over extended periods of time. Here, we discuss the complexities of consolidation and reconsolidation, and suggest they should be viewed not as all-or-none phenomena, but as a continuing series of biological adjustments that enhance both the efficiency and the utility of stored memories over time and in response to changing needs of the organism. As such, consolidation and reconsolidation might be better thought of as memory organization and reorganization. A rapidly growing body of evidence suggests that many of these processes are optimally engaged during sleep.
记忆巩固和重新巩固反映了分子、细胞和系统层面的过程，这些过程将不稳定的记忆表征转化为更持久的表征，以便在较长时间内持续重新激活和回忆。在这里，我们讨论巩固和重新巩固的复杂性，并认为它们不应被视为全或无的现象，而应被视为一系列持续的生物调节过程，这些过程随着时间的推移并响应生物体不断变化的需求，提高了存储记忆的效率和效用。因此，巩固和重新巩固可能更应被视为记忆组织和重组。越来越多的证据表明，这些过程中的许多在睡眠期间能得到最佳发挥。
