传递沉默：用于向血管生成性内皮细胞递送小干扰RNA的载体设计
Transporting silence: design of carriers for siRNA to angiogenic endothelium.
作者信息
Schiffelers Raymond M, Mixson Archibald J, Ansari Aslam M, Fens Marcel H A M, Tang Quingquan, Zhou Qin, Xu Jun, Molema Grietje, Lu Patrick Y, Scaria Puthupparampil V, Storm Gert, Woodle Martin C
机构信息
Department Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands.
出版信息
J Control Release. 2005 Dec 5;109(1-3):5-14. doi: 10.1016/j.jconrel.2005.05.018. Epub 2005 Jun 24.
The recently developed siRNA oligonucleotides are an attractive alternative to antisense as a therapeutic modality because of their robust, gene selective silencing of drug target protein expression. To achieve therapeutic success, however, several hurdles must be overcome including rapid clearance, nuclease degradation, and inefficient intracellular localization. In this presentation, we discuss design strategies for development of self-assembling nanoscale carriers for neovasculature targeted delivery of siRNA inhibiting tumor or ocular angiogenesis.
最近开发的小干扰RNA（siRNA）寡核苷酸作为一种治疗方式，是反义技术颇具吸引力的替代方案，因为它们能对药物靶蛋白表达进行强大的、基因选择性的沉默。然而，要取得治疗成功，必须克服几个障碍，包括快速清除、核酸酶降解以及细胞内定位效率低下。在本报告中，我们讨论了用于开发自组装纳米级载体的设计策略，该载体用于靶向新血管生成递送抑制肿瘤或眼部血管生成的siRNA。
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