用于转录本图谱分析的寡核苷酸平铺微阵列分析中的问题。
Issues in the analysis of oligonucleotide tiling microarrays for transcript mapping.
作者信息
Royce Thomas E, Rozowsky Joel S, Bertone Paul, Samanta Manoj, Stolc Viktor, Weissman Sherman, Snyder Michael, Gerstein Mark
机构信息
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
出版信息
Trends Genet. 2005 Aug;21(8):466-75. doi: 10.1016/j.tig.2005.06.007.
Abstract
Traditional microarrays use probes complementary to known genes to quantitate the differential gene expression between two or more conditions. Genomic tiling microarray experiments differ in that probes that span a genomic region at regular intervals are used to detect the presence or absence of transcription. This difference means the same sets of biases and the methods for addressing them are unlikely to be relevant to both types of experiment. We introduce the informatics challenges arising in the analysis of tiling microarray experiments as open problems to the scientific community and present initial approaches for the analysis of this nascent technology.
摘要
传统微阵列使用与已知基因互补的探针来定量两种或更多条件之间的差异基因表达。基因组平铺微阵列实验则不同，它使用以固定间隔跨越基因组区域的探针来检测转录的存在与否。这种差异意味着相同的偏差集以及解决这些偏差的方法不太可能与这两种类型的实验都相关。我们将平铺微阵列实验分析中出现的信息学挑战作为开放性问题引入科学界，并提出了分析这项新兴技术的初步方法。
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