功能基因组学作为病毒研究的一种工具。

Functional genomics as a tool in virus research.

机构信息

Virology Group, International Centre for Genetic Engineering & Biotechnology, New Delhi, India.

出版信息

Indian J Microbiol. 2008 Jun;48(2):195-201. doi: 10.1007/s12088-008-0032-3. Epub 2008 Jul 27.

DOI:10.1007/s12088-008-0032-3

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3450177/

Abstract

Genomics is the study of an organism's entire genome. It started out as a great scientific endeavor in the 1990s which aimed to sequence the complete genomes of certain biological species. However viruses are not new to this field as complete viral genomes have routinely been sequenced since the past thirty years. The 'genomic era' has been said to have revolutionized biology. This knowledge of full genomes has created the field of functional genomics in today's post-genomic era, which, is in most part concerned with the studies on the expression of the organism's genome under different conditions. This article is an attempt to introduce its readers to the application of functional genomics to address and answer several complex biological issues in virus research.

摘要

基因组学是对生物体全部基因组的研究。它始于 20 世纪 90 年代的一项伟大科学计划，旨在对某些生物物种的完整基因组进行测序。然而，病毒在该领域并不新鲜，因为自过去三十年来，完整的病毒基因组已被常规测序。有人说“基因组时代”彻底改变了生物学。在当今的后基因组时代，对完整基因组的了解催生了功能基因组学领域，该领域主要关注不同条件下生物体基因组表达的研究。本文旨在向读者介绍功能基因组学的应用，以解决和回答病毒研究中几个复杂的生物学问题。

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