DNA 元件百科全书（ENCODE）计划

The ENCODE (ENCyclopedia Of DNA Elements) Project.

出版信息

Science. 2004 Oct 22;306(5696):636-40. doi: 10.1126/science.1105136.

Abstract

The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional elements in the human genome sequence. The pilot phase of the Project is focused on a specified 30 megabases (approximately 1%) of the human genome sequence and is organized as an international consortium of computational and laboratory-based scientists working to develop and apply high-throughput approaches for detecting all sequence elements that confer biological function. The results of this pilot phase will guide future efforts to analyze the entire human genome.

摘要

DNA元件百科全书（ENCODE）计划旨在识别人类基因组序列中的所有功能元件。该计划的试点阶段聚焦于人类基因组序列中特定的3000万个碱基对（约占1%），并组织了一个由计算科学家和实验科学家组成的国际联盟，致力于开发和应用高通量方法来检测所有赋予生物学功能的序列元件。试点阶段的结果将为未来分析整个人类基因组的工作提供指导。