Birgisson H, Talbäck M, Gunnarsson U, Påhlman L, Glimelius B
Department of Surgery, Akademiska Sjukhuset, S-75185 Uppsala, Sweden.
Eur J Surg Oncol. 2005 Oct;31(8):845-53. doi: 10.1016/j.ejso.2005.05.002.
To analyse time-trends in survival of patients with colon and rectal cancer in Sweden.
Data including all patients diagnosed with adenocarcinoma of the colon and rectum between 1960 and 1999, from the Swedish Cancer Registry, were analysed. The observed and relative survival rates were calculated according to the Hakulinen cohort method.
Five-year relative survival rate for cancer of the colon improved significantly from 39.6% in 1960--1964 to 57.2% in 1995--1999 and for rectal cancer from 36.1 to 57.6%, respectively. Corresponding observed survival improved from 31.2 to 44.3% for colon cancer and from 28.4 to 45.4% for rectal cancer. The largest improvement of survival were seen during the later part of the period observed.
The survival of patients with colon and rectal cancer in Sweden continues to improve, especially in rectal cancer, which now has a 5-year observed and relative survival rate comparable to that for colon cancer. The survival improvement in rectal cancer is probably a result of the implementation of total mesorectal excision and pre-operative radiotherapy.
分析瑞典结肠癌和直肠癌患者的生存时间趋势。
分析了瑞典癌症登记处1960年至1999年间所有诊断为结肠和直肠腺癌患者的数据。根据哈库利宁队列法计算观察到的生存率和相对生存率。
结肠癌的五年相对生存率从1960 - 1964年的39.6%显著提高到1995 - 1999年的57.2%，直肠癌的五年相对生存率分别从36.1%提高到57.6%。相应地，结肠癌的观察到的生存率从31.2%提高到44.3%，直肠癌从28.4%提高到45.4%。观察期后期生存率改善最为显著。
瑞典结肠癌和直肠癌患者的生存率持续提高，尤其是直肠癌，其五年观察到的生存率和相对生存率现已与结肠癌相当。直肠癌生存率的提高可能是实施全直肠系膜切除术和术前放疗的结果。
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