Hinoi Toshihide, Matsuo Shusuke, Tadehara Futoshi, Tsujiyama Shuji, Yamakido Michio
Department of Internal Medicine, Kure Kyosai Hospital, Hiroshima, Japan.
Am J Cardiol. 2005 Jul 1;96(1):89-91. doi: 10.1016/j.amjcard.2005.02.050.
Thirty-two patients were randomly assigned to treatment with placebo or atorvastatin. The time-averaged peak diastolic velocity (APDV) of the left anterior descending artery without stenosis was measured by transthoracic Doppler echocardiography at rest and under hyperemic conditions before and 1 hour after treatment. APDV increased significantly in the atorvastatin group, at rest and under hyperemic conditions, and coronary flow velocity reserve also increased in the atorvastatin group compared with patients given placebo. Atorvastatin improved the blood flow velocity of the normal coronary artery <1 hour after administration in patients without coronary artery disease by angiography.
32名患者被随机分配接受安慰剂或阿托伐他汀治疗。在治疗前及治疗后1小时，通过经胸多普勒超声心动图在静息和充血状态下测量无狭窄的左前降支动脉的时间平均舒张期峰值速度（APDV）。与给予安慰剂的患者相比，阿托伐他汀组在静息和充血状态下APDV显著增加，且冠状动脉血流储备也增加。在无冠状动脉疾病的患者中，通过血管造影显示，阿托伐他汀在给药后<1小时即可改善正常冠状动脉的血流速度。
