Ford D K
Clin Orthop Relat Res. 1979 Sep(143):59-65.
Certain infections of the genitourinary and gastrointestinal tracts, such as nongonococcal urethritis, dysentery and yersiniosis, precipitate characteristic arthritic syndromes in genetically susceptible individuals. Eye and skin lesions in the form of conjunctivitis, iritis, keratodermia blenorrhagica and erythema nodosum occurring in association with particular distributions of arthritis make recognizable clinical entities. Reiter's syndrome may be diagnosed with certainty from the presence of tender heels, low back pain, a predominance of knee and foot arthritis and pyuria, when the more obvious clinical markers of the syndrome are absent; a flagrant case represents one of the easiest clinical diagnoses in medicine. Diagnosis is important for a good prognosis, optimal treatment and sometimes prophylactic measures. Sacroiliitis often progressing to spinal ankylosis is a prominant feature in the B27-positive patient. Erythema nodosum occurs in B27-negative subjects as a response to yersiniosis and ulcerative colitis.
某些泌尿生殖道和胃肠道感染，如非淋菌性尿道炎、痢疾和耶尔森菌病，会在遗传易感性个体中引发特征性关节炎综合征。结膜炎、虹膜炎、脓性皮肤角化病和结节性红斑等眼部和皮肤病变与特定分布的关节炎相关联，构成了可识别的临床病症。当该综合征较明显的临床标志物不存在时，若出现足跟压痛、腰痛、膝关节和足部关节炎为主以及脓尿，就可以确诊赖特综合征；典型病例是医学上最容易诊断的临床病症之一。诊断对于良好的预后、最佳治疗以及有时的预防措施都很重要。骶髂关节炎常发展为脊柱强直，是B27阳性患者的一个突出特征。结节性红斑在B27阴性个体中作为对耶尔森菌病和溃疡性结肠炎的反应而出现。
