Balíková Marie
Institute of Forensic Medicine and Toxicology, 1st Medical Faculty, Charles University in Prague, 121 08 Prague 2, Czech Republic.
Forensic Sci Int. 2005 Oct 4;153(1):85-91. doi: 10.1016/j.forsciint.2005.04.022.
2,5-Dimethoxy-4-bromoamphetamine (DOB) is a strongly acting hallucinogen with an estimated effective dose of 2 mg for an 80 kg man. The case of two men who ingested a new "hallucinogen LSD-like" designer drug is reported here. They experienced intense hallucinations (onset after 15 min) and vomiting. The men became unconscious and fell into deep coma lasting several days. After an unknown period of time elapsed they were admitted to a hospital in a comatose state. One subject (AX, body mass 113 kg) survived, while the second subject (BX, body mass 65 kg) experienced convulsions, metabolic acidosis and died 6 days later. Gastric, blood, and urine specimens collected on admission into the hospital were sent for toxicological examination. Ethanol concentrations in the blood samples were less than 0.2 g/kg. CEDIA urine screening indicated the presence of THCOOH in both cases, while cocaine and its metabolites were only indicated in the urine from AX. Immunoassay for amphetamines was negative in urine specimens collected from both subjects. GC-MS analysis for unknown drugs allowed for the discovery of the presence of DOB in the gastric and urine samples of both persons. DOB-targeted analysis for the acetylated analyte confirmed its presence in both subjects. Quantitative analysis yielded concentrations in serum of 13 ng/ml (AX) and 19 ng/ml (BX). This report on both nonfatal and fatal DOB overdose cases is based on clear toxicological evidence, and is the first documentation of DOB consumption in the Czech Republic.
2,5 - 二甲氧基 - 4 - 溴苯丙胺（DOB）是一种强效致幻剂，据估计，对于一名体重80公斤的男性，有效剂量为2毫克。本文报告了两名男子摄入一种新型“类似麦角酸二乙酰胺（LSD）的致幻剂”的案例。他们出现了强烈的幻觉（15分钟后发作）并呕吐。两人失去意识，陷入深度昏迷，持续了数天。在经过一段未知时间后，他们以昏迷状态被送往医院。一名受试者（AX，体重113公斤）存活下来，而另一名受试者（BX，体重65公斤）出现抽搐、代谢性酸中毒，并于6天后死亡。入院时采集的胃内容物、血液和尿液样本被送去进行毒理学检查。血液样本中的乙醇浓度低于0.2克/千克。CEDIA尿液筛查表明，两例样本中均存在四氢大麻酚羧酸（THCOOH），而仅在AX的尿液中检测出可卡因及其代谢物。对两名受试者采集的尿液样本进行的苯丙胺免疫测定均为阴性。对未知药物的气相色谱 - 质谱（GC - MS）分析发现，两人的胃内容物和尿液样本中均存在DOB。针对乙酰化分析物的DOB靶向分析证实了其在两名受试者中的存在。定量分析得出血清浓度分别为13纳克/毫升（AX）和19纳克/毫升（BX）。这份关于非致命和致命DOB过量案例的报告基于明确的毒理学证据，是捷克共和国首次记录DOB的使用情况。
