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Study on metabolites of 2,5-dimethoxy-4-bromamphetamine (DOB) in human urine using gas chromatography-mass spectrometry.

作者信息

Beránková Katerina, Balíková Marie

机构信息

Institute of Forensic Medicine and Toxicology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

出版信息

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):465-8. doi: 10.5507/bp.2005.081.

DOI:10.5507/bp.2005.081
PMID:16601811
Abstract

The study of the biotransformation of a new synthetic drug 2,5-dimethoxy-4-bromamphetamine (DOB) and identification of its metabolites in urine of a poisoned person is described using gas chromatography mass spectrometry (GC-MS) with various ways of derivatization. It has been confirmed that one of its metabolic pathways leads to the corresponding 2-O-desmethyl and 5-O-desmethyl metabolites when the latter is prevailing. It is important to know the metabolism of this neurotoxic and hallucinogenic substance as it is a prerequisite for developing reliable toxicological diagnostic procedures and for assessment of toxicological risks.

摘要

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