Karp Christopher L, Flick Leah M, Yang Rong, Uddin Jasim, Petasis Nicos A
Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45208, USA.
Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct;73(3-4):263-70. doi: 10.1016/j.plefa.2005.05.015.
Dysregulated neutrophilic inflammation and chronic infection lead to progressive destruction of the airways in cystic fibrosis (CF). Despite considerable recent progress in therapy, the median survival of patients with CF remains around 30 years. The lipoxins are endogenous anti-inflammatory lipid mediators that are important regulators of neutrophilic inflammation. Recent data indicate that there is a pathophysiologically important defect in lipoxin-mediated anti-inflammatory activity in the CF airway, suggesting novel approaches to pathogenesis and therapy in this lethal genetic disease.
中性粒细胞炎症失调和慢性感染导致囊性纤维化（CF）患者气道的进行性破坏。尽管近年来治疗取得了相当大的进展，但CF患者的中位生存期仍约为30年。脂氧素是内源性抗炎脂质介质，是中性粒细胞炎症的重要调节因子。最近的数据表明，CF气道中脂氧素介导的抗炎活性存在病理生理学上的重要缺陷，这为这种致命遗传病的发病机制和治疗提出了新的方法。
