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唑来膦酸治疗戈谢病。 (注:原文中“Gorham's disease”常见释义为“戈谢病”,但从专业角度更准确的是“ Gorham-Stout病”,这里按给定原文翻译)

Treatment of Gorham's disease with zoledronic acid.

作者信息

Mignogna M D, Fedele S, Lo Russo L, Ciccarelli R

机构信息

Oral Medicine Division, Department of Odontostomatological and Maxillofacial Sciences, University Federico II of Naples, Via Pansini 5, 80129 Naples, Italy.

出版信息

Oral Oncol. 2005 Aug;41(7):747-50. doi: 10.1016/j.oraloncology.2005.04.007.

Abstract

Gorham's disease (GD) is a rare disorder characterized by spontaneous and progressive osteolysis of one or more bones and thought to belong to lymphangiomatoses spectrum of diseases. Surgical, radiation and medical therapies have been performed with variable and often discouraging outcomes and currently there is no recognized effective treatment. In this paper we describe a 24-year-old girl with GD localized to mandible who was effectively managed with zoledronic acid, a nitrogen-containing high-potency bisphosphonate.

摘要

戈勒姆病(GD)是一种罕见的疾病,其特征为一个或多个骨骼的自发性进行性骨质溶解,被认为属于淋巴管瘤病谱系疾病。手术、放疗和药物治疗均已实施,但效果各异且往往令人沮丧,目前尚无公认的有效治疗方法。在本文中,我们描述了一名24岁的女性戈勒姆病患者,其病变局限于下颌骨,使用唑来膦酸(一种含氮高效双膦酸盐)进行了有效治疗。

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