Griffiths Anne M
Inflammatory Bowel Disease Program, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
JPEN J Parenter Enteral Nutr. 2005 Jul-Aug;29(4 Suppl):S108-12; discussion S112-7, S184-8. doi: 10.1177/01486071050290S4S108.
Exclusive feeding of defined formula diets has been used successfully as an alternative to corticosteroid treatment of active Crohn's disease, but the mechanism of efficacy remains conjectural. Recognition that polymorphisms in the NOD2/CARD15 gene confer susceptibility to Crohn's disease has increased appreciation of the interactions between the innate immune system and enteric bacteria, which lead to chronic intestinal inflammation. The 2 major goals of this workshop are: first, in light of current understanding of pathogenesis, to examine possible mechanisms of action of enteral nutrition as primary therapy; and second, to make evidence-based recommendations concerning its use in the new era of biologic therapies, when mucosal healing has become a realistic goal. Factors influencing efficacy, including duration, location of intestinal inflammation, and formula composition require consideration.
使用特定配方饮食进行独家喂养已成功用作活动性克罗恩病皮质类固醇治疗的替代方法，但疗效机制仍属推测。认识到NOD2/CARD15基因多态性赋予克罗恩病易感性，这增加了对先天免疫系统与肠道细菌之间相互作用的认识，而这种相互作用会导致慢性肠道炎症。本次研讨会的两个主要目标是：第一，根据目前对发病机制的理解，研究肠内营养作为主要治疗方法的可能作用机制；第二，在黏膜愈合已成为现实目标的生物治疗新时代，就其使用提出基于证据的建议。影响疗效的因素，包括持续时间、肠道炎症部位和配方组成，都需要考虑。
