Department of Community Nursing, Preventive Medicine and Public Health and History of Science (SPAIN), University of Alicante, San Vicente del Raspeig, 03690 Alicante, Spain.
Department of Nursing (SPAIN), University of Alicante, San Vicente del Raspeig, 03690 Alicante, Spain.
Nutrients. 2019 Nov 4;11(11):2657. doi: 10.3390/nu11112657.
Inflammatory bowel disease (IBD) is a chronic disease mediated by the immune system and is characterized by inflammation of the gastrointestinal tract. One of the possible treatments for this pathology is a change in the type of diet, of which enteral nutrition (EN) is one. This study is to understand how the use of EN can affect the adult population diagnosed with IBD. We conducted a systematic review, meta-analysis, and a meta-regression. On the different databases (MEDLINE, Scopus, Cochrane, LILACS, CINAHL, WOS), we found 363 registers with an accuracy of 12% (44 registers). After a full-text review, only 30 research studies were selected for qualitative synthesis and 11 for meta-analysis and meta-regression. The variables used were Crohn's disease activity index (CDAI), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). EN has been shown to have efficacy for the treatment of Crohn's disease and is compatible with other medicines. As for the CDAI or rates of remission, there were no differences between enteral and parenteral nutrition. Polymeric formulas have shown better results with respect to the CRP. The long-term treatment could dilute the good CDAI results that are obtained at the start of the EN treatment.
炎症性肠病（IBD）是一种由免疫系统介导的慢性疾病，其特征为胃肠道炎症。这种疾病的可能治疗方法之一是改变饮食类型，其中肠内营养（EN）就是一种。本研究旨在了解 EN 的使用如何影响诊断为 IBD 的成年人群。我们进行了系统评价、荟萃分析和荟萃回归。在不同的数据库（MEDLINE、Scopus、Cochrane、LILACS、CINAHL、WOS）中，我们发现了 363 个登记册，准确率为 12%（44 个登记册）。经过全文审查，只有 30 项研究被选中进行定性综合分析，11 项研究进行荟萃分析和荟萃回归。使用的变量是克罗恩病活动指数（CDAI）、C 反应蛋白（CRP）和红细胞沉降率（ESR）。EN 已被证明对治疗克罗恩病有效，并且与其他药物兼容。至于 CDAI 或缓解率，肠内营养和肠外营养之间没有差异。聚合配方在 CRP 方面显示出更好的效果。长期治疗可能会淡化 EN 治疗开始时获得的良好 CDAI 结果。
