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本文引用的文献

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Measurement of the respiratory volumes of laboratory animals.实验动物呼吸量的测量。
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Efficacy of high doses of liposomal amphotericin B in the treatment of experimental aspergillosis.高剂量脂质体两性霉素B治疗实验性曲霉病的疗效
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Review of newer antifungal and immunomodulatory strategies for invasive aspergillosis.侵袭性曲霉病新型抗真菌和免疫调节策略综述
Clin Infect Dis. 2003 Oct 1;37 Suppl 3:S157-87. doi: 10.1086/376523.
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Amphotericin B: time for a new "gold standard".两性霉素B：是时候采用新的“金标准”了。
Clin Infect Dis. 2003 Aug 1;37(3):415-25. doi: 10.1086/376634. Epub 2003 Jul 22.
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British Society for Medical Mycology proposed standards of care for patients with invasive fungal infections.英国医学真菌学会提出了侵袭性真菌感染患者的护理标准。
Lancet Infect Dis. 2003 Apr;3(4):230-40. doi: 10.1016/s1473-3099(03)00580-2.
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The incidence of invasive aspergillosis among solid organ transplant recipients and implications for prophylaxis in lung transplants.实体器官移植受者侵袭性曲霉病的发病率及肺移植预防的意义。
Transpl Infect Dis. 2002 Dec;4(4):195-200. doi: 10.1034/j.1399-3062.2002.t01-2-02002.x.
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Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis.伏立康唑与两性霉素B用于侵袭性曲霉病的初始治疗比较
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Enhanced antifungal efficacy in experimental invasive pulmonary aspergillosis by combination of AmBisome with Fungizone as assessed by several parameters of antifungal response.通过抗真菌反应的几个参数评估，两性霉素B脂质体与两性霉素B联合使用可增强实验性侵袭性肺曲霉病的抗真菌疗效。
J Antimicrob Chemother. 2002 May;49(5):813-20. doi: 10.1093/jac/dkf010.
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Nebulized amphotericin B prophylaxis for Aspergillus infection in lung transplantation: study of risk factors.雾化两性霉素B预防肺移植受者曲霉感染：危险因素研究
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10
Efficacy of aerosolized amphotericin B desoxycholate and liposomal amphotericin B in the treatment of invasive pulmonary aspergillosis in severely immunocompromised rats.雾化脱氧胆酸两性霉素B和两性霉素B脂质体治疗严重免疫受损大鼠侵袭性肺曲霉病的疗效
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雾化脂质体两性霉素B治疗实验性肺曲霉病的疗效

Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis.

作者信息

Gavaldà Joan, Martín María-Teresa, López Pedro, Gomis Xavier, Ramírez José-Luís, Rodríguez Dolors, Len Oscar, Puigfel Yolanda, Ruíz Isabel, Pahissa Albert

机构信息

Infectious Diseases Research Laboratory, Infectious Diseases Division, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

出版信息

Antimicrob Agents Chemother. 2005 Jul;49(7):3028-30. doi: 10.1128/AAC.49.7.3028-3030.2005.

DOI:10.1128/AAC.49.7.3028-3030.2005
PMID:15980392
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1168712/
Abstract

The efficacy of therapeutic aerosolized amphotericin B (AMB) was studied in a steroid-immunosuppressed murine model of invasive pulmonary aspergillosis. Nebulized liposomal AMB can be a valid approach to the treatment of this infection, with subjects showing significantly improved survival relative to that of subjects given intravenous deoxycholate AMB, as well as lower lung weights and pulmonary glucosamine levels.

摘要

在类固醇免疫抑制的侵袭性肺曲霉病小鼠模型中研究了雾化两性霉素B（AMB）治疗的疗效。雾化脂质体AMB可能是治疗这种感染的有效方法，与静脉注射脱氧胆酸盐AMB的受试者相比，接受雾化脂质体AMB治疗的受试者生存率显著提高，肺重量和肺氨基葡萄糖水平也更低。