口服链阳性菌素类抗菌药物XRP2868对革兰氏阳性菌的体外活性
In vitro activity of an oral streptogramin antimicrobial, XRP2868, against gram-positive bacteria.
作者信息
Eliopoulos G M, Ferraro M J, Wennersten C B, Moellering R C
机构信息
Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
出版信息
Antimicrob Agents Chemother. 2005 Jul;49(7):3034-9. doi: 10.1128/AAC.49.7.3034-3039.2005.
Abstract
The comparative in vitro potency of XRP2868, a new oral semisynthetic streptogramin antibiotic, was evaluated against gram-positive bacteria. XRP2868 inhibited all staphylococci at < or = 1 microg/ml and all non-pneumococcal streptococci at < or = 0.25 microg/ml and was fourfold more potent than quinupristin-dalfopristin against Staphylococcus aureus and Enterococcus faecium.
摘要
一种新型口服半合成链阳菌素抗生素XRP2868对革兰氏阳性菌的体外比较效力进行了评估。XRP2868在浓度≤1微克/毫升时可抑制所有葡萄球菌，在浓度≤0.25微克/毫升时可抑制所有非肺炎链球菌，并且对金黄色葡萄球菌和粪肠球菌的效力比奎奴普丁-达福普汀强四倍。
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