质粒编码的喹诺酮耐药蛋白QnrA与大肠杆菌拓扑异构酶IV的相互作用。
Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coli topoisomerase IV.
作者信息
Tran John H, Jacoby George A, Hooper David C
机构信息
Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
出版信息
Antimicrob Agents Chemother. 2005 Jul;49(7):3050-2. doi: 10.1128/AAC.49.7.3050-3052.2005.
Abstract
Purified QnrA blocked ciprofloxacin inhibition of topoisomerase IV, just as QnrA was previously found to prevent quinolone inhibition of DNA gyrase. With a gel displacement assay, tagged QnrA was shown to bind to topoisomerase IV and its subunits in a reaction that did not depend on the presence of DNA, quinolone, or ATP.
摘要
纯化的QnrA可阻断环丙沙星对拓扑异构酶IV的抑制作用，正如之前发现QnrA可防止喹诺酮对DNA回旋酶的抑制作用一样。通过凝胶迁移试验表明，标记的QnrA在不依赖DNA、喹诺酮或ATP存在的反应中可与拓扑异构酶IV及其亚基结合。
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3
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J Biol Chem. 1993 Nov 15;268(32):24481-90.
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