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大环内酯类耐药葡萄球菌属分离株中红霉素诱导的替利霉素耐药性

Induction of telithromycin resistance by erythromycin in isolates of macrolide-resistant Staphylococcus spp.

作者信息

Davis Kepler A, Crawford Sharon A, Fiebelkorn Kristin R, Jorgensen James H

机构信息

Infectious Disease Service, Department of Medicine, Brooke Army Medical Center, Ft. Sam Houston, Texas 78234, USA.

出版信息

Antimicrob Agents Chemother. 2005 Jul;49(7):3059-61. doi: 10.1128/AAC.49.7.3059-3061.2005.

DOI:10.1128/AAC.49.7.3059-3061.2005
PMID:15980400
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1168692/
Abstract

Staphylococcal isolates were examined for possible macrolide-inducible resistance to telithromycin. All macrolide-resistant isolates demonstrated telithromycin D-shaped zones. This result did not discriminate between resistance due to an efflux mechanism (msrA) or a ribosomal target modification (ermA or ermC). Inducible telithromycin resistance in staphylococci does not appear to be analogous to inducible clindamycin resistance.

摘要

对葡萄球菌分离株进行了检测，以确定其对泰利霉素是否存在大环内酯诱导性耐药。所有大环内酯耐药分离株均显示出泰利霉素D形抑菌圈。该结果无法区分由外排机制（msrA）或核糖体靶位修饰（ermA或ermC）导致的耐药。葡萄球菌中诱导性泰利霉素耐药似乎与诱导性克林霉素耐药不同。

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本文引用的文献

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J Clin Microbiol. 2004 Apr;42(4):1800-2. doi: 10.1128/JCM.42.4.1800-1802.2004.
2
Failure of clindamycin treatment of methicillin-resistant Staphylococcus aureus expressing inducible clindamycin resistance in vitro.体外对表达诱导型克林霉素耐药的耐甲氧西林金黄色葡萄球菌进行克林霉素治疗失败。
Clin Infect Dis. 2003 Nov 1;37(9):1257-60. doi: 10.1086/377501. Epub 2003 Oct 3.
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