大环内酯类耐药葡萄球菌属分离株中红霉素诱导的替利霉素耐药性
Induction of telithromycin resistance by erythromycin in isolates of macrolide-resistant Staphylococcus spp.
作者信息
Davis Kepler A, Crawford Sharon A, Fiebelkorn Kristin R, Jorgensen James H
机构信息
Infectious Disease Service, Department of Medicine, Brooke Army Medical Center, Ft. Sam Houston, Texas 78234, USA.
出版信息
Antimicrob Agents Chemother. 2005 Jul;49(7):3059-61. doi: 10.1128/AAC.49.7.3059-3061.2005.
Abstract
Staphylococcal isolates were examined for possible macrolide-inducible resistance to telithromycin. All macrolide-resistant isolates demonstrated telithromycin D-shaped zones. This result did not discriminate between resistance due to an efflux mechanism (msrA) or a ribosomal target modification (ermA or ermC). Inducible telithromycin resistance in staphylococci does not appear to be analogous to inducible clindamycin resistance.
摘要
对葡萄球菌分离株进行了检测，以确定其对泰利霉素是否存在大环内酯诱导性耐药。所有大环内酯耐药分离株均显示出泰利霉素D形抑菌圈。该结果无法区分由外排机制（msrA）或核糖体靶位修饰（ermA或ermC）导致的耐药。葡萄球菌中诱导性泰利霉素耐药似乎与诱导性克林霉素耐药不同。
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