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捷克共和国耐甲氧西林凝固酶阴性葡萄球菌中对大环内酯类和林可酰胺类耐药机制的流行情况以及对林可酰胺类一种不明耐药机制的出现。

Prevalence of resistance mechanisms against macrolides and lincosamides in methicillin-resistant coagulase-negative staphylococci in the Czech Republic and occurrence of an undefined mechanism of resistance to lincosamides.

作者信息

Novotna Gabriela, Adamkova Václava, Janata Jiri, Melter Oto, Spizek Jaroslav

机构信息

Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 14220, Czechoslovakia.

出版信息

Antimicrob Agents Chemother. 2005 Aug;49(8):3586-9. doi: 10.1128/AAC.49.8.3586-3589.2005.

DOI:10.1128/AAC.49.8.3586-3589.2005
PMID:16048992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1196274/
Abstract

High occurrence of the non-macrolide-lincosamide-streptogramin B resistance genes msrA (53%) and linA/linA' (30%) was found among 98 methicillin-resistant coagulase-negative staphylococci additionally resistant to macrolides and/or lincosamides. The gene msrA predominated in Staphylococcus haemolyticus (43 of 62 isolates). In Staphylococcus epidermidis, it was present in 7 of 27 isolates. A novel mechanism of resistance to lincosamides appears to be present in 10 genetically related isolates of S. haemolyticus in the absence of ermA, ermC, msrA, and linA/linA'.

摘要

在98株对大环内酯类和/或林可酰胺类耐药的耐甲氧西林凝固酶阴性葡萄球菌中，发现非大环内酯 - 林可酰胺 - 链阳菌素B耐药基因msrA（53%）和linA/linA'（30%）的高发生率。msrA基因在溶血葡萄球菌中占主导地位（62株分离株中的43株）。在表皮葡萄球菌中，27株分离株中有7株存在该基因。在10株基因相关的溶血葡萄球菌分离株中，在不存在ermA、ermC、msrA和linA/linA'的情况下，似乎存在一种新的对林可酰胺类的耐药机制。

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