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环丙沙星的亚致死浓度可诱导大肠杆菌产生细菌素。

Sublethal concentrations of ciprofloxacin induce bacteriocin synthesis in Escherichia coli.

作者信息

Jerman Borut, Butala Matej, Zgur-Bertok Darja

机构信息

Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, Ljubljana, Slovenia.

出版信息

Antimicrob Agents Chemother. 2005 Jul;49(7):3087-90. doi: 10.1128/AAC.49.7.3087-3090.2005.

DOI:10.1128/AAC.49.7.3087-3090.2005
PMID:15980407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1168710/
Abstract

Antibiotics that interfere with DNA replication, as well as cell wall synthesis, induce the SOS response. In this report, we show that ciprofloxacin induces synthesis of colicins, narrow-spectrum antibiotics frequently produced by Escherichia coli strains, in an SOS-dependent manner.

摘要

干扰DNA复制以及细胞壁合成的抗生素会诱导SOS反应。在本报告中，我们表明环丙沙星以SOS依赖的方式诱导大肠杆菌菌株经常产生的窄谱抗生素——大肠杆菌素的合成。

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Sublethal concentrations of ciprofloxacin induce bacteriocin synthesis in Escherichia coli.环丙沙星的亚致死浓度可诱导大肠杆菌产生细菌素。
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2
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本文引用的文献

1
Diversion of the metabolic flux from pyruvate dehydrogenase to pyruvate oxidase decreases oxidative stress during glucose metabolism in nongrowing Escherichia coli cells incubated under aerobic, phosphate starvation conditions.在有氧、磷酸盐饥饿条件下培养的非生长型大肠杆菌细胞中，将代谢通量从丙酮酸脱氢酶转向丙酮酸氧化酶可降低葡萄糖代谢过程中的氧化应激。
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Antibiotic-induced lateral transfer of antibiotic resistance.抗生素诱导的抗生素耐药性横向转移。
Trends Microbiol. 2004 Sep;12(9):401-4. doi: 10.1016/j.tim.2004.07.003.
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SOS response induction by beta-lactams and bacterial defense against antibiotic lethality.β-内酰胺诱导的SOS反应及细菌对抗生素致死性的防御
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4
Antibiotic-mediated antagonism leads to a bacterial game of rock-paper-scissors in vivo.抗生素介导的拮抗作用导致体内细菌展开一场“石头-剪刀-布”的博弈。
Nature. 2004 Mar 25;428(6981):412-4. doi: 10.1038/nature02429.
5
Transcriptional profiling of colicin-induced cell death of Escherichia coli MG1655 identifies potential mechanisms by which bacteriocins promote bacterial diversity.大肠杆菌MG1655中大肠菌素诱导的细胞死亡的转录谱分析确定了细菌素促进细菌多样性的潜在机制。
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SOS response promotes horizontal dissemination of antibiotic resistance genes.SOS 应答促进抗生素抗性基因的水平传播。
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7
A cka-gfp transcriptional fusion reveals that the colicin K activity gene is induced in only 3 percent of the population.一个Acka - gfp转录融合实验表明，大肠杆菌素K活性基因仅在3%的群体中被诱导表达。
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8
Toxin gene expression by shiga toxin-producing Escherichia coli: the role of antibiotics and the bacterial SOS response.产志贺毒素大肠杆菌的毒素基因表达：抗生素和细菌SOS反应的作用
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Identification of additional genes belonging to the LexA regulon in Escherichia coli.大肠杆菌中属于LexA调控子的其他基因的鉴定。
Mol Microbiol. 2000 Mar;35(6):1560-72. doi: 10.1046/j.1365-2958.2000.01826.x.
10
Transcription regulation of the colicin K cka gene reveals induction of colicin synthesis by differential responses to environmental signals.大肠杆菌素K cka基因的转录调控揭示了通过对环境信号的不同反应诱导大肠杆菌素合成。
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