环丙沙星的亚致死浓度可诱导大肠杆菌产生细菌素。
Sublethal concentrations of ciprofloxacin induce bacteriocin synthesis in Escherichia coli.
作者信息
Jerman Borut, Butala Matej, Zgur-Bertok Darja
机构信息
Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, Ljubljana, Slovenia.
出版信息
Antimicrob Agents Chemother. 2005 Jul;49(7):3087-90. doi: 10.1128/AAC.49.7.3087-3090.2005.
Abstract
Antibiotics that interfere with DNA replication, as well as cell wall synthesis, induce the SOS response. In this report, we show that ciprofloxacin induces synthesis of colicins, narrow-spectrum antibiotics frequently produced by Escherichia coli strains, in an SOS-dependent manner.
摘要
干扰DNA复制以及细胞壁合成的抗生素会诱导SOS反应。在本报告中，我们表明环丙沙星以SOS依赖的方式诱导大肠杆菌菌株经常产生的窄谱抗生素——大肠杆菌素的合成。
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