Gruber Markus, Söding Johannes, Lupas Andrei N
Max-Planck Institute for Developmental Biology Spemannstr. 35, 72076 Tübingen, Germany.
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W239-43. doi: 10.1093/nar/gki405.
REPPER (REPeats and their PERiodicities) is an integrated server that detects and analyzes regions with short gapless repeats in protein sequences or alignments. It finds periodicities by Fourier Transform (FTwin) and internal similarity analysis (REPwin). FTwin assigns numerical values to amino acids that reflect certain properties, for instance hydrophobicity, and gives information on corresponding periodicities. REPwin uses self-alignments and displays repeats that reveal significant internal similarities. Both programs use a sliding window to ensure that different periodic regions within the same protein are detected independently. FTwin and REPwin are complemented by secondary structure prediction (PSIPRED) and coiled coil prediction (COILS), making the server a versatile analysis tool for sequences of fibrous proteins. REPPER is available at http://protevo.eb.tuebingen.mpg.de/repper.
REPPER（重复序列及其周期性）是一个集成服务器，用于检测和分析蛋白质序列或比对中无间隙短重复区域。它通过傅里叶变换（FTwin）和内部相似性分析（REPwin）来发现周期性。FTwin为反映某些特性（如疏水性）的氨基酸赋予数值，并给出相应周期性的信息。REPwin使用自比对并显示揭示显著内部相似性的重复序列。这两个程序都使用滑动窗口来确保独立检测同一蛋白质内不同的周期性区域。FTwin和REPwin由二级结构预测（PSIPRED）和卷曲螺旋预测（COILS）补充，使该服务器成为纤维状蛋白质序列的多功能分析工具。可通过http://protevo.eb.tuebingen.mpg.de/repper访问REPPER。
