Horváth G, Szikszay M, Rubicsek G, Benedek G
Department of Physiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Life Sci. 1992;50(23):PL215-20. doi: 10.1016/0024-3205(92)90071-v.
The effects of the combinations of dexmedetomidine-fentanyl and dexmedetomidine-diazepam on the righting reflex were studied in rats. The doses that block the righting reflex for the agents given alone and for their combinations were determined with a probit procedure and compared with an isobolographic analysis. The interactions between dexmedetomidine and fentanyl or diazepam were found to be synergistic. In the dexmedetomidine-diazepam combination studies, less than one-fourth of the single drug dose (for each of two agents) was needed to produce the required effect. These data confirm synergistic interactions between dexmedetomidine and fentanyl or diazepam in producing hypnotic-anesthetic action.
在大鼠中研究了右美托咪定-芬太尼和右美托咪定-地西泮联合用药对翻正反射的影响。采用概率单位法确定单独给药及其联合用药阻断翻正反射的剂量，并与等效应线图分析进行比较。发现右美托咪定与芬太尼或地西泮之间存在协同作用。在右美托咪定-地西泮联合用药研究中，产生所需效应所需的单药剂量（两种药物各自）不到四分之一。这些数据证实了右美托咪定与芬太尼或地西泮在产生催眠-麻醉作用方面存在协同相互作用。
