Kissin I, Brown P T, Bradley E L, Robinson C A, Cassady J L
Department of Anesthesiology, School of Medicine, University of Alabama, Birmingham.
Anesthesiology. 1989 Apr;70(4):689-94. doi: 10.1097/00000542-198904000-00025.
The effect of diazepam-morphine combination on the righting reflex was studied in rats. Doses of the drugs given alone and in combination that block righting reflex (RR ED50) were determined with a probit procedure. Brain concentrations following equieffective doses of the drugs administered separately and in combination were determined by radioimmunoassay. Equieffective intravenous doses and corresponding brain concentrations for the agents were compared with fractional (algebraic) and isobolographic analyses. Interaction between diazepam and morphine was found to be synergistic. It is not likely to be pharmacokinetic in nature.
研究了地西泮-吗啡联合用药对大鼠翻正反射的影响。采用概率单位法确定单独给药和联合给药时阻断翻正反射（RR ED50）的药物剂量。通过放射免疫分析法测定单独给药和联合给药等效剂量后的脑内浓度。采用分数（代数）和等效应线分析比较了药物的等效静脉注射剂量和相应的脑内浓度。发现地西泮和吗啡之间的相互作用具有协同性。这种相互作用不太可能是药代动力学性质的。
