Fernandez Carmen, Reader Al, Beck Mike, Nusstein John
College of Dentistry, The Ohio State University, 305 W. 12th Avenue, Columbus, OH 43218, USA.
J Endod. 2005 Jul;31(7):499-503. doi: 10.1097/01.don.0000167395.61075.38.
The purpose of this prospective, randomized, double-blind study was to compare the degree of pulpal anesthesia obtained with 0.5% bupivacaine with 1:200,000 epinephrine and 2% lidocaine with 1:100,000 epinephrine in inferior alveolar nerve blocks. Using a crossover design, inferior alveolar nerve blocks were randomly administered, in a double-blind manner, using 0.5% bupivacaine with 1:200,000 epinephrine and 2% lidocaine with 1:100,000 epinephrine, at two separate appointments, to 39 subjects. A pulp tester was used to test for anesthesia until two consecutive readings of less than 80 were recorded on at least three of the five experimental teeth. Anesthesia was considered successful when two consecutive 80 readings were obtained within 15 min and the 80 reading was continuously sustained for 60 min. Anesthetic success was significantly improved for all teeth except the first molar with the lidocaine solution. Pulpal anesthesia averaged 4 hr for bupivacaine versus 2 hr and 24 min for lidocaine.
这项前瞻性、随机、双盲研究的目的是比较在牙槽下神经阻滞中，0.5%布比卡因加1:200,000肾上腺素与2%利多卡因加1:100,000肾上腺素所获得的牙髓麻醉程度。采用交叉设计，以双盲方式在两次单独的就诊中，将0.5%布比卡因加1:200,000肾上腺素和2%利多卡因加1:100,000肾上腺素随机用于39名受试者的牙槽下神经阻滞。使用牙髓测试仪测试麻醉效果，直到在五颗实验牙齿中的至少三颗上连续记录到两次低于80的读数。当在15分钟内获得连续两次80的读数且80的读数持续60分钟时，麻醉被认为成功。除第一磨牙外，利多卡因溶液对所有牙齿的麻醉成功率均有显著提高。布比卡因的牙髓麻醉平均持续4小时，而利多卡因平均持续2小时24分钟。
