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[从受辐照机体中清除醌类放射毒素对血液吸附治疗放射病疗效的重要性]

[The importance of removing quinoid radiotoxins from the irradiated organism in the efficacy of hemosorption in the therapy of radiation sickness].

作者信息

Kopylov V A, Revin A F, Vagabova M E, Kuzin A M

出版信息

Radiobiologiia. 1992 Mar-Apr;32(2):276-9.

PMID:1598403
Abstract

Sorption by SKN-2M coal of various endogenous substances, including quinones (tyrosine oxidation products) and quinoid radiotoxins (QR) isolated from gamma-irradiated plant and animal tissues has been studied. The fact that the precursors of QR-DOPA, tyrosine and QR, isolated from gamma-irradiated plant and animal tissues, are readily absorbed by the sorbent under study supports the major contribution of QR removal from the organism to the therapeutic effect of hemosorption after gamma irradiation of animals with minimal lethal doses.

摘要

研究了SKN - 2M煤对各种内源性物质的吸附情况,这些物质包括从经γ射线辐照的动植物组织中分离出的醌类(酪氨酸氧化产物)和醌类放射毒素(QR)。从经γ射线辐照的动植物组织中分离出的QR的前体——多巴、酪氨酸和QR,很容易被所研究的吸附剂吸收,这一事实支持了在以最小致死剂量对动物进行γ射线辐照后,从生物体中去除QR对血液吸附治疗效果的主要贡献。

相似文献

1
[The importance of removing quinoid radiotoxins from the irradiated organism in the efficacy of hemosorption in the therapy of radiation sickness].[从受辐照机体中清除醌类放射毒素对血液吸附治疗放射病疗效的重要性]
Radiobiologiia. 1992 Mar-Apr;32(2):276-9.
2
[Modifying effect of water-soluble analogs of quinoid radiotoxins on hematopoiesis in gamma-irradiated mice].[醌类放射毒素水溶性类似物对γ射线照射小鼠造血功能的影响]
Radiobiologiia. 1987 Jul-Aug;27(4):558-60.
3
[Quinoid radiotoxins in the blood of gamma-irradiated dogs].[γ射线照射犬血液中的醌类放射毒素]
Radiobiologiia. 1987 Sep-Oct;27(5):614-7.
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[The effect of low doses of a synthetic analog of a quinoid radiotoxin on the viability of normal and gamma-irradiated animals].[低剂量醌类放射性毒素合成类似物对正常及γ射线照射动物生存能力的影响]
Radiats Biol Radioecol. 1996 May-Jun;36(3):349-54.
5
[Synergism in the effect of gamma-radiation and quinoid radiotoxins on mice and cultured lymphoid cells].
Radiobiologiia. 1986 Jul-Aug;26(4):520-3.
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[Biochemical characteristics of substances sorbed on SKN-2M activated charcoal during hemosorption in the normal state and following burn injury].[正常状态及烧伤后血液吸附过程中吸附于SKN-2M活性炭上物质的生化特性]
Vopr Med Khim. 1985 Mar-Apr;31(2):94-7.
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[The nature of the toxic properties of the blood plasma of gamma irradiated rats].[γ射线辐照大鼠血浆毒性特性的本质]
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[Hemosorption in the treatment of endogenous toxemia in acute pancreatitis].[血液吸附在急性胰腺炎内源性毒血症治疗中的应用]
Vestn Khir Im I I Grek. 1987 May;138(5):29-33.
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[The role of biologically active substances (radiotoxins) in radiation sickness].[生物活性物质(放射毒素)在放射病中的作用]
Radiobiologiia. 1970 Mar-Apr;10(2):212-29.
10
[Study of radiotoxins of a quinoid nature].[醌类性质的放射毒素研究]
Radiobiologiia. 1967 Nov-Dec;7(6):831-4.