联合检测沙眼衣原体针对10 kDa和60 kDa热休克蛋白的特异性抗体作为输卵管因素不孕症的诊断工具：喀麦隆一项病例对照研究的结果
Combined detection of Chlamydia trachomatis-specific antibodies against the 10 and 60-kDa heat shock proteins as a diagnostic tool for tubal factor infertility: Results from a case-control study in Cameroon.
作者信息
Dadamessi Innocenti, Eb François, Betsou Fotini
机构信息
Department of Medicine, Centre Hospitalier de Péronne, France.
出版信息
FEMS Immunol Med Microbiol. 2005 Jul 1;45(1):31-5. doi: 10.1016/j.femsim.2005.01.009. Epub 2005 Feb 10.
A case-control study was conducted to determine the diagnostic value of Chlamydia trachomatis-associated anti-Chsp10 and/or anti-Chsp60 antibodies in the detection of secondary infertility. There were significant associations between C. trachomatis infection and infertility (p<0.01), and between C. trachomatis-specific anti-Chsp10 or anti-Chsp60 antibodies and secondary infertility (p<0.001). A significant correlation was found between anti-Chsp10 and anti-Chsp60 titers (p<0.01). The detection of either C. trachomatis-associated anti-Chsp10 or anti-Chsp60 antibodies cumulatively allowed specific diagnosis of secondary infertility (57.4% sensitivity, 75.5% specificity).
进行了一项病例对照研究，以确定沙眼衣原体相关的抗Chsp10和/或抗Chsp60抗体在继发性不孕检测中的诊断价值。沙眼衣原体感染与不孕之间存在显著关联（p<0.01），沙眼衣原体特异性抗Chsp10或抗Chsp60抗体与继发性不孕之间也存在显著关联（p<0.001）。抗Chsp10和抗Chsp60滴度之间存在显著相关性（p<0.01）。检测沙眼衣原体相关的抗Chsp10或抗Chsp60抗体可累积实现继发性不孕的特异性诊断（敏感性57.4%，特异性75.5%）。
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