31岁普通人群中沙眼衣原体热休克蛋白Hsp60和Hsp10抗体与生育力低下的关系
Antibodies to Chlamydia trachomatis heat shock proteins Hsp60 and Hsp10 and subfertility in general population at age 31.
作者信息
Karinen L, Pouta A, Hartikainen A-L, Bloigu A, Paldanius M, Leinonen M, Saikku P, Järvelin M-R
机构信息
Department of Obstetrics and Gynecology, University Hospital of Oulu, Finland.
出版信息
Am J Reprod Immunol. 2004 Nov;52(5):291-7. doi: 10.1111/j.1600-0897.2004.00223.x.
PROBLEM
To assess the association between antibodies to Chlamydia trachomatis heat shock proteins 60 and 10 (Hsp60 and Hsp10) and subfertility in a general population sample.
METHOD OF STUDY
A nested case (n = 146)-control (n = 278) study in a population-based birth cohort. Serum immunoglobulin (Ig)G and IgA antibodies against C. trachomatis Hsp60 and Hsp10, explanatory factors, were measured by enzyme immunoassay, using recombinant proteins as antigens. The main outcome variable was subfertility (time to pregnancy > or =12 months).
RESULTS
The prevalence and medians of serum IgA antibodies to Hsp60 and Hsp10 were significantly higher in the female partners of subfertile couple than in their fertile controls. On the contrary, among male partners of subfertile couple, especially among smokers serum antibody levels to Hsp antigens were lower than in the controls.
CONCLUSION
The results indicate a serological association of antibodies to chlamydial Hsp antigens with female subfertility in a population-based sample.
问题
在一般人群样本中评估沙眼衣原体热休克蛋白60和10（Hsp60和Hsp10）抗体与生育力低下之间的关联。
研究方法
在一个基于人群的出生队列中进行巢式病例（n = 146）对照（n = 278）研究。以重组蛋白为抗原，通过酶免疫测定法检测针对沙眼衣原体Hsp60和Hsp10的血清免疫球蛋白（Ig）G和IgA抗体以及解释因素。主要结局变量是生育力低下（怀孕时间≥12个月）。
结果
不育夫妇女性伴侣中血清IgA抗体针对Hsp60和Hsp10的患病率及中位数显著高于其可育对照。相反，在不育夫妇男性伴侣中，尤其是吸烟者，血清针对Hsp抗原的抗体水平低于对照。
结论
结果表明在基于人群的样本中，衣原体Hsp抗原抗体与女性生育力低下存在血清学关联。
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