D'Aloia Antonio, Faggiano Pompilio, Brentana Loretta, Boldini Alessandra, Pedrinazzi Claudio, Procopio Roberto, Dei Cas Livio
Int J Cardiol. 2005 Dec 7;105(3):337-9. doi: 10.1016/j.ijcard.2004.11.031. Epub 2005 Jun 27.
This report describes a 64 year-old female patient admitted to our department for recurrent and symptomatic episodes of atrial fibrillation. Antiarrhythmic therapy with sotalol at 240 mg/day was started, and after 48 h the patient experienced several episodes of sustained torsade de pointes, dramatic marked QT interval prolongation and negative T wave, in absence of overt cardiac disease, renal failure, electrolyte abnormalities or baseline QT interval prolongation. This case emphasizes the importance of hospitalization at the starting of sotalol therapy, especially in female patients, even in absence of predisposing factors for drug-induced tachyarrhythmias.
本报告描述了一名64岁女性患者，因反复发作且有症状的房颤发作而入住我科。开始使用索他洛尔进行抗心律失常治疗，剂量为每日240毫克，48小时后，患者出现多次持续性尖端扭转型室速发作、显著的QT间期延长和负向T波，且无明显的心脏病、肾衰竭、电解质异常或基线QT间期延长。该病例强调了索他洛尔治疗开始时住院治疗的重要性，尤其是在女性患者中，即使不存在药物性快速心律失常的诱发因素。
