Appel J M, Sigurd B
Medicinsk afdeling, Centralsygehuset i Nykøbing Falster.
Ugeskr Laeger. 1996 Jul 8;158(28):4093-4.
Proarrhythmia in the form of Torsade de Pointes tachycardia (TdP) is a well-known complication of sotalol treatment. It most often occurs in the setting of sotalol overdosing, renal impairment, bradycardia, hypokalaemia, hypomagnesiaemia or lengthening of the QT-interval due to other drugs. TdP is reported without these predisposing factors. In the described case, TdP might be facilitated by bradycardia and by potassium depletion without concomitant hypokalaemia after diuretic treatment.
尖端扭转型室性心动过速(TdP)形式的致心律失常是索他洛尔治疗的一种众所周知的并发症。它最常发生在索他洛尔过量、肾功能损害、心动过缓、低钾血症、低镁血症或因其他药物导致QT间期延长的情况下。也有在没有这些易感因素时报告发生TdP的情况。在所描述的病例中,利尿治疗后心动过缓和钾缺乏(无伴随低钾血症)可能促使了TdP的发生。