Nasseri Behrooz, Florence Alexander T
Centre for Drug Delivery Research, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Int J Pharm. 2005 Jul 25;298(2):372-7. doi: 10.1016/j.ijpharm.2005.03.037.
Lipid nanotubes or "tethers" can be formed from liposomes or niosomes, pulled from the parent vesicles by micromanipulation. The tethers are cylindrical multibilayer tubes. Here, we describe the movement of these multilamellar walls, initiated by creating a surface tension gradient along the tether. The movement of lipid can give rise to a visible moving boundary. In the case of bilayer membranes, a tangential gradient in surface tension produces membrane bulk flow toward regions of higher surface tension. The flow of the bilayers comprising the tether nanotubes seems to be restricted to the inner bilayers, creating a velocity gradient in the bilayers. In this study, we discuss the implementation of tension-driven flows as a transport method in a tether-vesicle network. Interactions between fluid within the tether channels and the lipid layers are important, leading to anomalies in the transport of fluids and particles compared to bulk systems.
脂质纳米管或“系链”可由脂质体或非离子表面活性剂囊泡形成，通过显微操作从母囊泡中拉出。这些系链是圆柱形的多层管。在此，我们描述了通过沿系链创建表面张力梯度引发的这些多层壁的运动。脂质的运动会产生可见的移动边界。对于双层膜，表面张力的切向梯度会使膜体流向表面张力较高的区域。构成系链纳米管的双层的流动似乎仅限于内部双层，从而在双层中产生速度梯度。在本研究中，我们讨论了张力驱动流作为系链 - 囊泡网络中一种传输方法的实现。系链通道内的流体与脂质层之间的相互作用很重要，与整体系统相比，这会导致流体和颗粒传输出现异常。
