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Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila.
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Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease.
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Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways.
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R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway.
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Expression, purification, and analysis of recombinant Drosophila Dicer-1 and Dicer-2 enzymes.
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Recognition of the pre-miRNA structure by Drosophila Dicer-1.
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Functional anatomy of the Drosophila microRNA-generating enzyme.
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In vivo Dicer-2 interactome during viral infection reveals novel pro and antiviral factors in Drosophila melanogaster.
PLoS Pathog. 2025 May 7;21(5):e1013093. doi: 10.1371/journal.ppat.1013093. eCollection 2025 May.
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Structural basis of endo-siRNA processing by Drosophila Dicer-2 and Loqs-PD.
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Cell-Autonomous and Non-Cell-Autonomous Antiviral Immunity via siRNA-Directed RNAi in .
Immune Discov. 2025 Mar;1(1). doi: 10.70322/immune.2025.10001. Epub 2025 Jan 2.
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piRNA-Guided Transposon Silencing and Response to Stress in Germline.
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Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA.
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The Evolution and Characterization of the RNA Interference Pathways in Lophotrochozoa.
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2
Processing of pre-microRNAs by the Dicer-1-Loquacious complex in Drosophila cells.
PLoS Biol. 2005 Jul;3(7):e235. doi: 10.1371/journal.pbio.0030235. Epub 2005 May 24.
3
Perspective: machines for RNAi.
Genes Dev. 2005 Mar 1;19(5):517-29. doi: 10.1101/gad.1284105.
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siRNA and miRNA: an insight into RISCs.
Trends Biochem Sci. 2005 Feb;30(2):106-14. doi: 10.1016/j.tibs.2004.12.007.
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Transcription and processing of human microRNA precursors.
Mol Cell. 2004 Dec 22;16(6):861-5. doi: 10.1016/j.molcel.2004.12.002.
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The Drosha-DGCR8 complex in primary microRNA processing.
Genes Dev. 2004 Dec 15;18(24):3016-27. doi: 10.1101/gad.1262504. Epub 2004 Dec 1.
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A protein sensor for siRNA asymmetry.
Science. 2004 Nov 19;306(5700):1377-80. doi: 10.1126/science.1102755.
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Processing of primary microRNAs by the Microprocessor complex.
Nature. 2004 Nov 11;432(7014):231-5. doi: 10.1038/nature03049. Epub 2004 Nov 7.
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The Microprocessor complex mediates the genesis of microRNAs.
Nature. 2004 Nov 11;432(7014):235-40. doi: 10.1038/nature03120. Epub 2004 Nov 7.

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