Yang X P, An R H, He R R, Xie Y K, Liu S X, Liu S
Department of Physiology, Institute of Basic Medicine, Hebei Medical College, Shijiazhuang, China.
Zhongguo Yao Li Xue Bao. 1992 Mar;13(2):123-5.
Using intracellular microelectrode technique and microcomputer analyzing system, the effects of m-nisoldipine (m-Nis) and nisoldipine (Nis) on spontaneous electric activity of human atrial tissue were studied. APA and Vmax were remarkably decreased by m-Nis (0.25 and 1.25 mumol.L-1) and Nis (0.25 mumol.L-1). RPF was also greatly decreased as a result of inhibition in VDD. The inhibitory effects of m-Nis on transmembrane potentials were less than those of Nis at equal concentration (0.25 mumol.L-1). Neither MDP nor APD90 was affected by m-Nis and Nis.
采用细胞内微电极技术和微机分析系统，研究了间尼索地平（m-Nis）和尼索地平（Nis）对人心房组织自发电活动的影响。m-Nis（0.25和1.25μmol·L-1）和Nis（0.25μmol·L-1）可显著降低动作电位振幅（APA）和最大上升速率（Vmax）。由于对舒张期去极化速率（VDD）的抑制，舒张期除极速率（RPF）也显著降低。在等浓度（0.25μmol·L-1）下，m-Nis对跨膜电位的抑制作用小于Nis。m-Nis和Nis对最大舒张电位（MDP）和90%动作电位时程（APD90）均无影响。
