An R H, Fan Z Z, He R R
Department of Physiology, Hebei Medical College, Shijiazhuang, China.
Zhongguo Yao Li Xue Bao. 1992 Jul;13(4):341-4.
Effects of m-Nis on the transmembrane currents were studied using single sucrose gap voltage clamp technique. The amplitude of slow inward current (I(si)) was 10.6 +/- 4.1 microA. Maximal inward current was induced at a membrane potential range between -20 to -25 mV. The amplitude of I(si) were significantly decreased by m-Nis (0.2 mumol.L-1) with a reduction of 47.3%. The transient inward current (I(ti)) induced by ouabain was also greatly depressed or prevented by m-Nis, resulting in the inhibition of DAD.
使用单蔗糖间隙电压钳技术研究了间硝基苯磺酸钠（m-Nis）对跨膜电流的影响。缓慢内向电流（I(si)）的幅度为10.6±4.1微安。在-20至-25毫伏的膜电位范围内诱导出最大内向电流。间硝基苯磺酸钠（0.2微摩尔/升）使I(si)的幅度显著降低，降低了47.3%。哇巴因诱导的瞬时内向电流（I(ti)）也被间硝基苯磺酸钠大大抑制或阻断，导致延迟后除极（DAD）受到抑制。
