发酵乳杆菌CRL 722能够在大鼠小肠中发挥活性α-半乳糖苷酶的作用。
Lactobacillus fermentum CRL 722 is able to deliver active alpha-galactosidase activity in the small intestine of rats.
作者信息
LeBlanc Jean Guy, Piard Jean-Christophe, Sesma Fernando, de Giori Graciela Savoy
机构信息
Centro de Referencia para Lactobacilos (CERELA-CONICET). Chacabuco 145, San Miguel de Tucumán, Tucumán, Argentina (T4000ILC).
出版信息
FEMS Microbiol Lett. 2005 Jul 15;248(2):177-82. doi: 10.1016/j.femsle.2005.05.054.
alpha-galactooligosaccharides (alpha-GOS) found in legumes such as soybeans can cause gastrointestinal disorders since mammals lack alpha-galactosidase (alpha-Gal) in the small intestine which is necessary for their hydrolysis. Lactobacillus fermentum CRL 722 is a lactic acid bacterium (LAB) capable of degrading alpha-GOS due to its elevated alpha-Gal activity. When conventional rats were fed live L. fermentum CRL 722 or cell-free extracts of this strain, a short-lived alpha-Gal activity was detected in the upper gastrointestinal tract. The safety of this LAB was also assessed. L. fermentum CRL 722 could thus be used as a vehicle to safely confer alpha-Gal in the small intestine of monogastric animal.
在大豆等豆类中发现的α-低聚半乳糖（α-GOS）会引发胃肠道紊乱，因为哺乳动物小肠中缺乏将其水解所必需的α-半乳糖苷酶（α-Gal）。发酵乳杆菌CRL 722是一种乳酸菌（LAB），因其较高的α-Gal活性而能够降解α-GOS。当给常规大鼠喂食活的发酵乳杆菌CRL 722或该菌株的无细胞提取物时，在上消化道中检测到了短暂的α-Gal活性。还评估了这种乳酸菌的安全性。因此，发酵乳杆菌CRL 722可用作一种载体，在单胃动物的小肠中安全地提供α-Gal。
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