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儿童超重的筛查与干预:美国预防服务工作组的证据总结

Screening and interventions for childhood overweight: a summary of evidence for the US Preventive Services Task Force.

作者信息

Whitlock Evelyn P, Williams Selvi B, Gold Rachel, Smith Paula R, Shipman Scott A

机构信息

Center for Health Research, Kaiser Permanente, Portland, Oregon 97227, USA.

出版信息

Pediatrics. 2005 Jul;116(1):e125-44. doi: 10.1542/peds.2005-0242.

Abstract

BACKGROUND

Childhood and adolescent overweight and obesity are related to health risks, medical conditions, and increased risk of adult obesity, with its attendant effects on morbidity and mortality rates. The prevalence of childhood overweight and obesity has more than doubled in the past 25 years. Purpose. This evidence synthesis examines the evidence for the benefits and harms of screening and early treatment of overweight among children and adolescents in clinical settings.

METHODS

We developed an analytic framework and 7 key questions representing the logical evidence connecting screening and weight control interventions with changes in overweight and behavioral, physiologic, and health outcomes in childhood or adulthood. We searched the Cochrane Library from 1996 to April 2004. We searched Medline, PsycINFO, DARE, and CINAHL from 1966 to April 2004. One reviewer abstracted relevant information from each included article into standardized evidence tables, and a second reviewer checked key elements. Two reviewers quality-graded each article with US Preventive Services Task Force criteria.

RESULTS

Although BMI is a measure of relative weight rather than adiposity, it is recommended widely for use among children and adolescents to determine overweight and is the currently preferred measure. The risk of adult overweight from childhood overweight provides the best available evidence to judge the clinical validity of BMI as an overweight criterion for children and adolescents. BMI measures in childhood track to adulthood moderately or very well, with stronger tracking seen for children with >or=1 obese parent and children who are more overweight or older. The probability of adult obesity (BMI of >30 kg/m(2)) is >or=50% among children >13 years of age whose BMI percentiles meet or exceed the 95th percentile for age and gender. BMI-based overweight categorization for individuals, particularly for racial/ethnic minorities with differences in body composition, may have limited validity because BMI measures cannot differentiate between increased weight for height attributable to relatively greater fat-free mass (muscle, bone, and fluids) and that attributable to greater fat. No trials of screening programs to identify and to treat childhood overweight have been reported. Limited research is available on effective, generalizable interventions for overweight children and adolescents that can be conducted in primary care settings or through primary care referrals.

CONCLUSIONS

BMI measurements of overweight among older adolescents identify those at increased risk of developing adult obesity. Interventions to treat overweight adolescents in clinical settings have not been shown to have clinically significant benefits, and they are not widely available. Screening to categorize overweight among children under age 12 or 13 who are not clearly overweight may not provide reliable risk categorization for adult obesity. Screening in this age group is compromised by the fact that there is little generalizable evidence for primary care interventions. Because existing trials report modest short- to medium-term improvements (approximately 10-20% decrease in percentage of overweight or a few units of change in BMI), however, overweight improvements among children and adolescents seem possible.

摘要

背景

儿童期和青少年期超重与肥胖与健康风险、疾病状况以及成年期肥胖风险增加相关,随之对发病率和死亡率产生影响。在过去25年中,儿童期超重与肥胖的患病率增加了一倍多。目的:本证据综合分析探讨了在临床环境中对儿童和青少年超重进行筛查及早期治疗的益处和危害的证据。

方法

我们制定了一个分析框架和7个关键问题,代表了将筛查和体重控制干预措施与儿童期或成年期超重及行为、生理和健康结果变化联系起来的逻辑证据。我们检索了1996年至2004年4月的Cochrane图书馆。我们检索了1966年至2004年4月的Medline、PsycINFO、DARE和CINAHL。一名评审员将每篇纳入文章的相关信息提取到标准化证据表中,另一名评审员检查关键要素。两名评审员根据美国预防服务工作组的标准对每篇文章进行质量分级。

结果

尽管体重指数(BMI)是相对体重而非肥胖程度的衡量指标,但它被广泛推荐用于儿童和青少年以确定超重情况,并且是目前首选的测量方法。儿童期超重导致成年期超重的风险为判断BMI作为儿童和青少年超重标准的临床有效性提供了最佳现有证据。儿童期的BMI测量结果在成年期有中度或很好的追踪性,对于有≥1名肥胖父母的儿童以及超重或年龄较大的儿童,追踪性更强。在13岁以上BMI百分位数达到或超过其年龄和性别的第95百分位数的儿童中,成年期肥胖(BMI>30kg/m²)的概率≥50%。基于BMI对个体进行超重分类,特别是对身体组成存在差异的种族/族裔少数群体,可能有效性有限,因为BMI测量无法区分因相对较大的去脂体重(肌肉、骨骼和液体)导致的身高体重增加与因脂肪增多导致的身高体重增加。尚未有关于识别和治疗儿童期超重的筛查项目的试验报告。关于可在初级保健环境中进行或通过初级保健转诊对超重儿童和青少年有效的、可推广的干预措施的研究有限。

结论

年龄较大青少年中超重的BMI测量可识别出成年期肥胖风险增加的个体。在临床环境中治疗超重青少年的干预措施尚未显示出具有临床显著益处,并且也未广泛应用。对12岁或13岁以下并非明显超重的儿童进行超重分类筛查可能无法为成年期肥胖提供可靠的风险分类。该年龄组的筛查受到以下事实的影响,即几乎没有关于初级保健干预措施的可推广证据。然而,由于现有试验报告了适度的短期至中期改善(超重百分比下降约10 - 20%或BMI有几个单位的变化),儿童和青少年的超重情况似乎有可能得到改善。

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