Kaur Rupinder, Domergue Renee, Zupancic Margaret L, Cormack Brendan P
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 617 Hunterian Building, 725 N. Wolfe St., Baltimore, MD 21205, USA.
Curr Opin Microbiol. 2005 Aug;8(4):378-84. doi: 10.1016/j.mib.2005.06.012.
Well-characterized traits important to Candida albicans virulence, such as hyphal formation or secreted proteinase activity, play no known role in Candida glabrata virulence. Likewise, some C. glabrata characteristics, such as chromatin-based regulation of the large telomeric family of lectins encoded by the EPA (epithelial adhesin) genes, have no precise parallels in C. albicans. However, similarities between the two species, for example in population structure, in the large numbers of (putative) adhesins that they encode, and in phenotypic plasticity conferred by phenotypic switching, suggest that they share general strategies in adaptation to an opportunistic lifestyle.
对白色念珠菌毒力很重要的特征明确的特性，如菌丝形成或分泌蛋白酶活性，在光滑念珠菌毒力中没有已知作用。同样，一些光滑念珠菌的特性，如由EPA（上皮粘附素）基因编码的大型端粒凝集素家族基于染色质的调控，在白色念珠菌中没有确切的对应物。然而，这两个物种之间的相似性，例如在种群结构、它们编码的大量（假定的）粘附素以及由表型转换赋予的表型可塑性方面，表明它们在适应机会性生存方式方面共享一般策略。
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