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微生物小档案:- 欺骗大师。

Microbe Profile: - a master of deception.

机构信息

School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120, USA.

出版信息

Microbiology (Reading). 2024 Nov;170(11). doi: 10.1099/mic.0.001518.

Abstract

is a fungal microbe associated with multiple vertebrate microbiomes and their terrestrial environments. In humans, the species has emerged as an opportunistic pathogen that now ranks as the second-leading cause of candidiasis in Europe and North America (Beardsley . 2024, 62). People at highest risk of infection include the elderly, immunocompromised individuals and/or long-term residents of hospital and assisted-living facilities. is intrinsically drug-resistant, metabolically versatile and able to avoid detection by the immune system. Analyses of its 12.3 Mb genome indicate a stable pangenome Marcet-Houben . ( 2022, 20) and phylogenetic affinity with . Recent phylogenetic analyses suggest reclassifying as Lakashima and Sugita ( 2022, 63: 119-132).

摘要

是一种与多种脊椎动物微生物组及其陆地环境相关的真菌微生物。在人类中,该物种已成为一种机会性病原体,现在是欧洲和北美的第二大致病菌性念珠菌病的原因(Beardsley. 2024, 62)。感染风险最高的人群包括老年人、免疫功能低下的个体和/或长期居住在医院和辅助生活设施中的人。 固有耐药性、代谢多功能性,并能够逃避免疫系统的检测。对其 12.3 Mb 基因组的分析表明,它具有稳定的泛基因组(Marcet-Houben. 2022, 20)和与 的系统发育亲和力。最近的系统发育分析表明,应将 重新分类为 Lakashima 和 Sugita( 2022, 63: 119-132)。

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