[保护的巯基烷基嘧啶酮：免疫刺激活性的合成与测试]
[Protected mercaptoalkylpyrimidinones: synthesis and test for immunostimulating activity].
作者信息
Briel D, Drössler K, Rybak A, Holzer M, Dobner B
机构信息
Fakultät für Biowissenschaften der Universität Leipzig, Germany.
出版信息
Pharmazie. 2005 Jun;60(6):415-7.
PMID:15997828
Abstract
Protected mercaptoalkylpyrimidinones: synthesis and test for immunostimulating activity 3-Hydroxyalkyl-pyrimidine 1 reacts with phosphoroxychloride and thioglycolic acid or thiourea to yield pyrimidin-3-ylalkylthioacetic acids 3 or pyrimidin-3-ylalkylthiouroniumsalts 5 respectively. Some of the pyrimidines 3 and 5 showed immunomodulatory activity.
摘要
保护的巯基烷基嘧啶酮
免疫刺激活性的合成与测试 3-羟烷基嘧啶1与三氯氧磷和巯基乙酸或硫脲反应，分别生成嘧啶-3-基烷基硫代乙酸3或嘧啶-3-基烷基硫脲鎓盐5。部分嘧啶3和5显示出免疫调节活性。
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