用于比较基因组学的微生物在线网站。
The MicrobesOnline Web site for comparative genomics.
作者信息
Alm Eric J, Huang Katherine H, Price Morgan N, Koche Richard P, Keller Keith, Dubchak Inna L, Arkin Adam P
机构信息
Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
出版信息
Genome Res. 2005 Jul;15(7):1015-22. doi: 10.1101/gr.3844805.
At present, hundreds of microbial genomes have been sequenced, and hundreds more are currently in the pipeline. The Virtual Institute for Microbial Stress and Survival has developed a publicly available suite of Web-based comparative genomic tools (http://www.microbesonline.org) designed to facilitate multispecies comparison among prokaryotes. Highlights of the MicrobesOnline Web site include operon and regulon predictions, a multispecies genome browser, a multispecies Gene Ontology browser, a comparative KEGG metabolic pathway viewer, a Bioinformatics Workbench for in-depth sequence analysis, and Gene Carts that allow users to save genes of interest for further study while they browse. In addition, we provide an interface for genome annotation, which like all of the tools reported here, is freely available to the scientific community.
目前，已有数百个微生物基因组完成了测序，还有数百个正在测序中。微生物应激与生存虚拟研究所开发了一套基于网络的可公开获取的比较基因组工具（http://www.microbesonline.org），旨在促进原核生物间的多物种比较。微生物在线网站的亮点包括操纵子和调控子预测、多物种基因组浏览器、多物种基因本体浏览器、比较KEGG代谢途径查看器、用于深入序列分析的生物信息学工作台以及基因购物车，基因购物车允许用户在浏览时保存感兴趣的基因以便进一步研究。此外，我们提供了一个基因组注释界面，与本文报道的所有工具一样，科学界可免费使用。
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