Altes Talissa A, Mai Vu M, Munger Therese Maier, Brookeman James R, Hagspiel Klaus D
Department of Radiology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA.
J Vasc Interv Radiol. 2005 Jul;16(7):999-1005. doi: 10.1097/01.RVI.0000162416.64412.FC.
Development of a comprehensive magnetic resonance (MR) examination consisting of MR angiography (MRA) and MR ventilation and perfusion (MR V/Q) scan for the detection of pulmonary emboli (PE) and assessment of the technique in a rabbit model.
Reversible PE was induced by inflating a non-detachable silicon balloon in the left pulmonary artery of five New Zealand White rabbits. MR V/Q scans were obtained prior to, during, and after balloon deflation. MRA was performed during balloon inflation. MR ventilation imaging was performed after the inhalation of hyperpolarized helium-3. MR perfusion imaging was performed with Flow-sensitive Alternating Inversion Recovery with an Extra Radiofrequency pulse technique (FAIRER). High-resolution contrast-enhanced MR pulmonary angiography was used to confirm the occlusion of the pulmonary artery. All imaging was performed on a 1.5-T whole body scanner with broadband capabilities.
High-resolution ventilation images of the lungs were obtained. No ventilation defects were detected before, during, or after resolution of simulated PE. FAIRER imaging allowed visualization of pulmonary perfusion. No perfusion defects were detected prior to balloon inflation. During balloon inflation (PE), there was decreased perfusion in the left lower lobe. After reversal of the PE, there was improved perfusion to the left lower lobe. In analogy to nuclear medicine techniques, acute PE produced a mismatched defect in the MR V/Q scan. MRA verified the occlusive filling defect in the left pulmonary artery.
High-resolution MRA and MR V/Q imaging of the lung is feasible and allows comprehensive assessment of pulmonary embolism in one imaging session.
开发一种综合磁共振（MR）检查方法，包括磁共振血管造影（MRA）以及磁共振通气与灌注（MR V/Q）扫描，用于检测肺栓塞（PE）并在兔模型中评估该技术。
通过向5只新西兰白兔的左肺动脉内充入不可拆卸的硅球囊诱导可逆性PE。在球囊放气前、放气期间和放气后进行MR V/Q扫描。在球囊充气期间进行MRA。在吸入超极化氦-3后进行MR通气成像。采用具有额外射频脉冲技术的血流敏感交替反转恢复序列（FAIRER）进行MR灌注成像。使用高分辨率对比增强MR肺血管造影来确认肺动脉闭塞情况。所有成像均在具有宽带功能的1.5-T全身扫描仪上进行。
获得了肺部的高分辨率通气图像。在模拟PE解决之前、期间或之后均未检测到通气缺陷。FAIRER成像能够显示肺灌注情况。在球囊充气前未检测到灌注缺陷。在球囊充气（PE）期间，左下叶灌注减少。PE逆转后，左下叶灌注改善。与核医学技术类似，急性PE在MR V/Q扫描中产生了不匹配的缺陷。MRA证实了左肺动脉的闭塞性充盈缺损。
肺部的高分辨率MRA和MR V/Q成像可行，且能够在一次成像过程中对肺栓塞进行全面评估。
