Lee Edward Y, Sun Yanping, Zurakowski David, Hatabu Hiroto, Khatwa Umakanth, Albert Mitchell S
Department of Radiology, Children's Hospital Boston, Boston, MA, USA.
J Thorac Imaging. 2009 May;24(2):110-4. doi: 10.1097/RTI.0b013e3181909f4a.
To prospectively investigate the number, location, and size of ventilation defects and correlate these findings with pulmonary function tests (PFTs) when performing hyperpolarized helium-3 (HP 3He) magnetic resonance imaging (MRI) of the lung in healthy young adults.
Six healthy adult female volunteers underwent standard PFT and MRI of the lungs after inhalation of HP 3He. HP 3He MR images were evaluated by 4 reviewers in consensus. Number, location, and size of ventilation defects were recorded. Locations of ventilation defects included the right upper lobe, right middle lobe, right lower lobe, left upper lobe, left lower lobe, and lingula. Ventilation defects were localized into central, middle, or peripheral portions of the lungs. Size of ventilation defects was categorized with a maximum diameter of either <or=3 cm or >3 cm. HP 3He MRI findings were correlated with PFT results.
The study cohort comprised 6 healthy, young adult female volunteers (mean age 22.5 y, range: 20-25 y) who underwent both PFT and HP 3He MRI. Five (83.3%) out of 6 volunteers had at least 1 ventilation defect (mean=2.3; range: 1-4; 95% confidence interval: 1.3-3.8 defects/patient). Among a total of 14 ventilation defects observed from 5 healthy, young adult volunteers, ventilation defects were observed in left lower lobe in 6 (42.9%), right lower lobe in 3 (21.4%), right upper lobe in 3 (21.4%), and left upper lobe in 2 (14.3%) patients. No ventilation defects were observed in the right middle lobe and lingula. All observed ventilation defects were less than 3 cm in size and peripherally located. There was no correlation between number, location, or size of ventilation defects and PFT results.
Small (<or=3 cm) peripherally located ventilation defects can be seen in the majority of healthy, young adult volunteers, and should not be mistaken as abnormalities when evaluating HP 3He MRI. These ventilation defects are located in the peripheral upper lobes and lower lobes (lower lobes>upper lobes) while sparing right middle lobe and lingula. The number, location, and size of ventilation defects on HP 3He MRI were not correlated with PFT results in the normal range, which suggests HP 3He MRI may be more sensitive than PFT for evaluating small ventilation defects in young adults.
前瞻性研究健康年轻成年人进行肺超极化氦-3（HP 3He）磁共振成像（MRI）时通气缺陷的数量、位置和大小，并将这些结果与肺功能测试（PFT）结果相关联。
6名健康成年女性志愿者在吸入HP 3He后接受了标准的PFT和肺部MRI检查。4名评估人员对HP 3He MR图像进行了一致性评估。记录通气缺陷的数量、位置和大小。通气缺陷的位置包括右上叶、右中叶、右下叶、左上叶、左下叶和舌叶。通气缺陷定位在肺的中央、中间或外周部分。通气缺陷的大小根据最大直径分为≤3 cm或>3 cm两类。将HP 3He MRI结果与PFT结果进行关联分析。
研究队列包括6名健康的年轻成年女性志愿者（平均年龄22.5岁，范围：20 - 25岁），她们均接受了PFT和HP 3He MRI检查。6名志愿者中有5名（83.3%）至少有1个通气缺陷（平均=2.3；范围：1 - 4；95%置信区间：1.3 - 3.8个缺陷/患者）。在5名健康年轻成年志愿者中总共观察到14个通气缺陷，其中左下叶有6个（42.9%）、右下叶有3个（21.4%）、右上叶有3个（21.4%）、左上叶有2个（14.3%）患者存在通气缺陷。右中叶和舌叶未观察到通气缺陷。所有观察到的通气缺陷大小均小于3 cm且位于外周。通气缺陷的数量、位置或大小与PFT结果之间无相关性。
大多数健康年轻成年志愿者可见小的（≤3 cm）外周性通气缺陷，在评估HP 3He MRI时不应将其误认为异常。这些通气缺陷位于外周上叶和下叶（下叶>上叶），而右中叶和舌叶未累及。HP 3He MRI上通气缺陷的数量、位置和大小与正常范围内的PFT结果无相关性，这表明HP 3He MRI在评估年轻成年人小的通气缺陷方面可能比PFT更敏感。
