Tamminga R Y, Kamps W A, Drayer N M, Humphrey G B
Department of Paediatrics, University Hospital Groningen, The Netherlands.
Acta Paediatr. 1992 Jan;81(1):61-5. doi: 10.1111/j.1651-2227.1992.tb12080.x.
In four groups of patients with acute lymphoblastic leukaemia, anthropometric variables were investigated every 3 months for 2 years. Group 1 (n = 7) was treated with a high-risk protocol, group 2 (n = 13) with a standard-risk protocol including cranial irradiation, group 3 (n = 13) with a standard-risk protocol without cranial irradiation and group 4 (n = 8) was followed after completion of treatment. A height retardation of 0.4-0.6 SD was observed during therapy in groups 1-3. A catch-up of 0.5 SD was found in group 4. The retardation of armspan was significantly larger than the retardation of sitting height when groups 1-3 were taken together. Head circumference was not affected. The anthropometric variables reflecting nutritional status showed a growth above normal during and after treatment. Corticosteroid medication and not cranial irradiation is the most likely explanation for our findings.
在四组急性淋巴细胞白血病患者中，对人体测量学变量进行了为期2年、每3个月一次的调查。第1组（n = 7）采用高风险方案治疗，第2组（n = 13）采用包括颅脑照射的标准风险方案治疗，第3组（n = 13）采用不进行颅脑照射的标准风险方案治疗，第4组（n = 8）在治疗结束后进行随访。在第1 - 3组的治疗期间观察到身高迟缓0.4 - 0.6标准差。在第4组发现有0.5标准差的追赶生长。当将第1 - 3组合并在一起时，臂展的迟缓明显大于坐高的迟缓。头围未受影响。反映营养状况的人体测量学变量在治疗期间和治疗后显示出高于正常的生长。我们的研究结果最可能的解释是皮质类固醇药物治疗而非颅脑照射。
