Le Guellec C, Bun H, Giocanti M, Durand A
Laboratoire Hospitalo-Universitaire de Pharmacocinétique et Toxicocinétique, Chu Timone, Marseille, France.
Biomed Chromatogr. 1992 Jan-Feb;6(1):20-3. doi: 10.1002/bmc.1130060107.
A rapid, specific and reliable gas chromatographic assay procedure for Nifedipine in plasma has been developed. With a single-step solvent extraction, and electron capture detection, the method is sensitive to 0.5 ng/mL of plasma and the standard curve is linear from 0.5 to 500 ng/mL. Samples are protected from light to prevent formation of photodecomposition products. The method has been used to monitor drug concentrations in patients receiving therapeutic doses.
