D'Antonio D, Di Bartolomeo P, Iacone A, Olioso P, Di Girolamo G, Angrilli F, Papalinetti G, Fioritoni G, Betti S, Torlontano G
Divisione di Ematologia-Laboratorio di Microbiologia Clinica Ospedale, Pescara, Italy.
Bone Marrow Transplant. 1992 Apr;9(4):299-300.
Two episodes of meningitis due to penicillin-resistant Streptococcus pneumoniae occurring in two patients with chronic graft-versus-host disease (GVHD) are reported. Both patients were treated with ceftazidime. The first patient died, unresponsive to therapy. The second patient showed clinical improvement, reverting to her baseline mental status. This report draws attention to the fact that in chronic GVHD patients: (1) bacterial prophylaxis does not ensure protection against encapsulated bacteria; (2) rapid microbiological investigation is recommended with any upper respiratory tract infections.
报告了两例慢性移植物抗宿主病（GVHD）患者发生的由耐青霉素肺炎链球菌引起的脑膜炎。两名患者均接受了头孢他啶治疗。第一名患者对治疗无反应，死亡。第二名患者临床症状改善，恢复到基线精神状态。本报告提请注意以下事实：在慢性GVHD患者中：（1）细菌预防不能确保预防包膜细菌感染；（2）建议对任何上呼吸道感染进行快速微生物学检查。
