Sammaritano Lisa R
Weill Medical College of Cornell University, Hospital of Special Surgery, New York, NY 10021, USA.
South Med J. 2005 Jun;98(6):617-25; quiz 626-7, 645. doi: 10.1097/01.smj.0000166748.90089.65.
Antiphospholipid syndrome spans many medical disciplines. Classic criteria include the presence of anticardiolipin antibody or lupus anticoagulant with typical complications of thrombosis or pregnancy loss. Other common associated manifestations include livedo reticularis, thrombocytopenia, valvular heart disease, and nephropathy with renal insufficiency, hypertension, and proteinuria. Treatment of serious complications with anticoagulation is standard; generally warfarin for thrombosis and aspirin/heparin for pregnancy prophylaxis. Detailed recommendations regarding precise intensity and duration of anticoagulation are still a subject of debate.
抗磷脂综合征涉及多个医学学科。经典标准包括存在抗心磷脂抗体或狼疮抗凝物以及典型的血栓形成或流产并发症。其他常见的相关表现包括网状青斑、血小板减少、瓣膜性心脏病以及伴有肾功能不全、高血压和蛋白尿的肾病。使用抗凝剂治疗严重并发症是标准治疗方法；一般来说，对于血栓形成使用华法林，对于预防妊娠使用阿司匹林/肝素。关于抗凝的确切强度和持续时间的详细建议仍是一个有争议的话题。
